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Article

The Genetic Architecture of Gene Expression in Peripheral Blood.

American journal of human genetics - 2 Feb 2017

Lloyd-Jones Luke R, Holloway Alexander, McRae Allan, Yang Jian, Small Kerrin, Zhao Jing, Zeng Biao, Bakshi Andrew, Metspalu Andres, Dermitzakis Manolis, Gibson Greg, Spector Tim, Montgomery Grant, Esko Tonu, Visscher Peter M, Powell Joseph E

Abstract excerpt

We analyzed the mRNA levels for 36,778 transcript expression traits (probes) from 2,765 individuals to comprehensively investigate the genetic architecture and degree of missing heritability for gene expression in peripheral blood. We identified 11,204 cis and 3,791 trans independent expression quantitative trait loci (eQTL) by using linear mixed models to perform genome-wide association analyses. Furthermore,...

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PMID: 28065468
DOI: 10.1016/j.ajhg.2016.12.008
PMCID: PMC5294670

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