Article

A tissue-specific ubiquitin switch coordinates brain, craniofacial, and skin development

2022-09-26

Abstract excerpt

The molecular mechanisms that coordinate patterning of the embryonic ectoderm into spatially distinct lineages to form the nervous system, epidermis, and craniofacial structures are unclear. Here, biochemical disease-variant profiling reveals a posttranslational pathway that drives early ectodermal differentiation in the vertebrate head. The anteriorly expressed ubiquitin ligase CRL3-KLHL4 restricts signaling of t...

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Literature Corpus work: 41d28a33-c3b5-5bbe-86b3-9839fcb6915a
DOI: 10.1101/2022.09.26.509591

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