Article

Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: A longitudinal analysis and GWAS using clinical monitoring data from the UK

2022-09-25

Abstract excerpt

<h4>Background</h4> The antipsychotic clozapine is the only drug with proven effectiveness against the treatment-resistant symptoms that affect 20-30% of those with schizophrenia. Despite this, clozapine is markedly under-prescribed, partly due to concerns about its narrow therapeutic range and adverse drug reaction profile. Both concerns are linked to drug metabolism, which varies across worldwide populations and...

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Literature Corpus work: 73da487b-ab5d-5c36-a8d7-22c353f9e475
DOI: 10.1101/2022.09.23.22280299

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