Article

Precise generation of bystander-free mouse models with ABE9-SpRY

2025-10-07

Abstract excerpt

<h4>ABSTRACT</h4> Point mutations cause many genetic disorders, but modelling them in organisms is technically challenging. Creating mouse models that mimic these mutations is crucial for establishing a causal relationship between mutations and disease phenotype, thereby supporting the development of therapeutic strategies. Adenine base editors (ABEs) can correct single-nucleotide variants (SNVs) in disease model...

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Literature Corpus work: 4fbd7b54-3bf0-5149-957b-b0221a06292b
DOI: 10.1101/2025.10.07.680931

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