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GDP-mannose 4,6-Dehydratase is a Key Driver of MYCN-amplified Neuroblastoma Core Fucosylation and Tumorigenesis

2024-08-11

Abstract excerpt

<title>Abstract</title> <p><italic>MYCN-</italic>amplification is a genetic hallmark of ~ 40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such as <italic>MYCN</italic>-amplification alter glycosylation profiles. Herein, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) rev...

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Literature Corpus work
4f86a37f-d9c1-591d-8243-1d0390cad520
DOI
10.21203/rs.3.rs-4720665/v1
Open publication

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