Article

Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

2023-01-09

Abstract excerpt

<h4>Summary</h4> Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. To unravel phenotypically relevant MB subtypes, we compiled a harmonized proteome dataset of 167 MBs and integrated findings with DNA methylation and N-glycome data. Six proteome MB subtypes emerged, that could be assigned to two main molecular programs: transcription/translation (pS...

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Literature Corpus work: 2a044de1-4278-5d50-8aed-d2071c9e9832
DOI: 10.1101/2023.01.09.523234

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