Article

Hypothesis: Hypoxia induces <i>de novo</i> synthesis of NeuGc gangliosides in humans through CMAH domain substitute

2017-04-07

Abstract excerpt

Immunotherapy is a growing field in cancer research. A privileged tumor-associated antigen that has received much attention is N -glycolyl (NeuGc) GM3. This ganglioside is present in several types of cancer, but is almost undetectable in human healthy tissues. However, its non-hydroxylated variant, NeuAc GM3, is abundant in all mammals. Due to a deletion in the human gene encoding the key enzyme for synthesis of...

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Literature Corpus work: 15c51d24-1964-58a0-b734-f89a10cfbf4d
DOI: 10.1101/125617

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