SpaCir-VDJ: a broadly compatible circularization strategy for spatial immune repertoire profiling

Abstract excerpt

Deciphering the spatial organization of immune clonal lineages is critical for understanding the evolution of adaptive immune responses. However, mainstream spatial transcriptomics platforms struggle to reconcile cost-effective short-read sequencing with the simultaneous and efficient capture of V(D)J sequences. To address this gap, we developed SpaCir-VDJ, an approach that utilizes a “multiplex PCR enrichment plu...

Topics

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• Computational Biology
• Gene Expression Profiling
• Mutation
• Neoplasms
• Polymorphism, Single Nucleotide
• Transcriptome
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

117080f1-532d-507a-91c3-7e1bfc4cdcc6

DOI

10.64898/2026.04.26.720528