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Altered mRNA transport and local translation in i3Neurons with RNA-binding protein knockdown

14 Jul 2025

Abstract excerpt

Neurons rely on messenger RNA (mRNA) transport and local translation to facilitate rapid protein synthesis in processes far from the cell body. These processes allow precise spatial and temporal control of translation and are mediated by RNA-binding proteins (RBPs), including those associated with neurodegenerative diseases. Here, we use proteomics, transcriptomics, and microscopy to investigate the impact of RBP...

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PMID: 40737092
DOI: 10.1093/nar/gkaf709

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