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Article

hnRNP A1 dysfunction in oligodendrocytes contributes to the pathogenesis of multiple sclerosis

16 Nov 2022

Abstract excerpt

Oligodendrocyte (OL) damage and death are prominent features of multiple sclerosis (MS) pathology, yet mechanisms contributing to OL loss are incompletely understood. Dysfunctional RNA binding proteins (RBPs), hallmarked by nucleocytoplasmic mislocalization and altered expression, have been shown to result in cell loss in neurologic diseases, including in MS. Since we previously observed that the RBP...

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PMID: 36382566
DOI: 10.1002/glia.24300

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