Article

Transcriptomic and pathological analysis of the hnRNP network reveals glial involvement in FTLD pathological subtypes

2025-07-18

Abstract excerpt

Frontotemporal dementia (FTD) is a neurodegenerative disorder with a strong heritable component. Frontotemporal lobar degeneration (FTLD) refers to the pathological changes seen in FTD, characterised by atrophy of the frontal and temporal lobes and the presence of abnormal protein inclusions. In the case of FTLD with hyperphosphorylated TDP-43 positive inclusions (FTLD-TDP), five pathological subtypes (A, B, C, D,...

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Literature Corpus work: b2c55f85-8089-57cc-acdb-7664bff81d4b
DOI: 10.1101/2025.07.14.664732

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