Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.

doi:10.1016/j.neuron.2016.09.050

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Article

Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.

Neuron - 23 Nov 2016

Martinez Fernando J, Pratt Gabriel A, Van Nostrand Eric L, Batra Ranjan, Huelga Stephanie C, Kapeli Katannya, Freese Peter, Chun Seung J, Ling Karen, Gelboin-Burkhart Chelsea, Fijany Layla, Wang Harrison C, Nussbacher Julia K, Broski Sara M, Kim Hong Joo, Lardelli Rea, Sundararaman Balaji, Donohue John P, Javaherian Ashkan, Lykke-Andersen Jens, Finkbeiner Steven, Bennett C Frank, Ares Manuel, Burge Christopher B, Taylor J Paul, Rigo Frank, Yeo Gene W

Abstract excerpt

HnRNPA2B1 encodes an RNA binding protein associated with neurodegeneration. However, its function in the nervous system is unclear. Transcriptome-wide crosslinking and immunoprecipitation in mouse spinal cord discover UAGG motifs enriched within ∼2,500 hnRNP A2/B1 binding sites and an unexpected role for hnRNP A2/B1 in alternative polyadenylation. HnRNP A2/B1 loss results in alternative splicing (AS), including...

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PMID: 27773581
DOI: 10.1016/j.neuron.2016.09.050
PMCID: PMC5123850

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