Article

A Membrane Transporter Determines the Spectrum of Activity of a Potent DNA-Targeted Hybrid Anticancer Agent

2020-06-05

Abstract excerpt

Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive components of personalized combination regimens for combating aggressive forms of cancer. To gain insight into the cellular mechanism of a highly potent platinum–acridine hybrid agent, we performed a correlation analysis of NCI-60 compound screening results and gene expression profiles. We discovered a plasma membrane...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f659570-8031-542c-b981-2b4f0ed3c2a8
DOI: 10.26434/chemrxiv.12430067.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Membrane Transporter Determines the Spectrum of Activity of a Potent DNA-Targeted Hybrid Anticancer AgentDOI 10.26434/chemrxiv.12430067.v1Read

A membrane transporter determines the spectrum of activity of a potent platinum–acridine hybrid anticancer agentSemantic proximity Read

Human Organic Cation Transporter 1 Is Expressed in Lymphoma Cells and Increases Susceptibility to Irinotecan and PaclitaxelSemantic proximity Read

The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicologySemantic proximity Read

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugsSemantic proximity Read

Use of Yeast Chemigenomics and COXEN Informatics in Preclinical Evaluation of Anticancer AgentsSemantic proximity Read

A Re-Evaluation of the Role of hCTR1, the Human High-Affinity Copper Transporter, in Platinum-Drug Entry into Human CellsSemantic proximity Read

OCTN1 Is a High-Affinity Carrier of Nucleoside AnaloguesSemantic proximity Read

Human organic cation transporter 1 (hOCT1) as a mediator of bendamustine uptake and cytotoxicity in chronic lymphocytic leukemia (CLL) cells.Semantic proximity Read

Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.Semantic proximity Read

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms.Semantic proximity Read

Synthetic lethality screening identifies FDA-approved drugs that overcome ATP7B-mediated tolerance of tumor cells to cisplatinSemantic proximity Read

Role of copper transporters in platinum resistanceSemantic proximity Read