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Article

Use of Yeast Chemigenomics and COXEN Informatics in Preclinical Evaluation of Anticancer Agents

1 Jan 2011

Abstract excerpt

Bladder cancer metastasis is virtually incurable with current platinum-based chemotherapy. We used the novel COXEN informatic approach for in silico drug discovery and identified NSC-637993 and NSC-645809 (C1311), both imidazoacridinones, as agents with high-predicted activity in human bladder cancer. Because even highly effective monotherapy is unlikely to cure most patients with metastasis and NSC-645809 is...

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PMID: 21253455
DOI: 10.1593/neo.101214

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