Article

Synthetic lethality screening identifies FDA-approved drugs that overcome ATP7B-mediated tolerance of tumor cells to cisplatin

2019-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Tumor resistance to chemotherapy represents an important challenge in modern oncology. Although platinum (Pt)-based drugs have demonstrated excellent therapeutic potential, their effectiveness in a wide range of tumors is limited by the development of resistance mechanisms. One of these mechanisms includes increased cisplatin sequestration/efflux by the copper-transporting ATPase, ATP7B. However...

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Literature Corpus work: 41a49260-aae1-5e05-859f-c397e00fdd5d
DOI: 10.1101/568535

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