Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A membrane transporter determines the spectrum of activity of a potent platinum–acridine hybrid anticancer agent

16 Sept 2020

Abstract excerpt

Abstract Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive components of personalized combination regimens for combatting aggressive forms of cancer. To gain insight into the cellular mechanism of a potent platinum–acridine anticancer agent (compound 1 ), a correlation analysis of NCI-60 compound screening results and gene expression profiles was performed. A plasma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Metal complexes synthesis and properties
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32939009
DOI: 10.1038/s41598-020-72099-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A membrane transporter determines the spectrum of activity of a potent platinum–acridine hybrid anticancer agentPMID 32939009Read ↗

A Membrane Transporter Determines the Spectrum of Activity of a Potent DNA-Targeted Hybrid Anticancer AgentSemantic proximity Read ↗

Human Organic Cation Transporter 1 Is Expressed in Lymphoma Cells and Increases Susceptibility to Irinotecan and PaclitaxelSemantic proximity Read ↗

The role of the human ABCG2 multidrug transporter and its variants in cancer therapy and toxicologySemantic proximity Read ↗

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugsSemantic proximity Read ↗

OCTN1 Is a High-Affinity Carrier of Nucleoside AnaloguesSemantic proximity Read ↗

Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.Semantic proximity Read ↗

The multidrug resistance phenotype in human cancer.Semantic proximity Read ↗

Synthetic lethality screening identifies FDA-approved drugs that overcome ATP7B-mediated tolerance of tumor cells to cisplatinSemantic proximity Read ↗

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms.Semantic proximity Read ↗

A Re-Evaluation of the Role of hCTR1, the Human High-Affinity Copper Transporter, in Platinum-Drug Entry into Human CellsSemantic proximity Read ↗

Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen.Semantic proximity Read ↗

Drug transporter expression profiling in chemoresistant variants of the A2780 ovarian cancer cell lineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.