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Article

OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues

16 Feb 2017

Abstract excerpt

Abstract Resistance to xenobiotic nucleosides used to treat acute myeloid leukemia (AML) and other cancers remains a major obstacle to clinical management. One process suggested to participate in resistance is reduced uptake into tumor cells via nucleoside transporters, although precise mechanisms are not understood. Through transcriptomic profiling, we determined that low expression of the ergothioneine...

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PMID: 28209616
DOI: 10.1158/0008-5472.can-16-2548

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