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Role of copper transporters in platinum resistance

1 Jan 2016

Abstract excerpt

Platinum (Pt)-based antitumor agents are effective in the treatment of many solid malignancies. However, their efficacy is limited by toxicity and drug resistance. Reduced intracellular Pt accumulation has been consistently shown to correlate with resistance in tumors. Proteins involved in copper homeostasis have been identified as Pt transporters. In particular, copper transporter receptor 1 (CTR1), the major...

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PMID: 26862494
DOI: 10.5306/wjco.v7.i1.106

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