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CD4 T cells and toxicity from immune checkpoint blockade

25 Jul 2023

Abstract excerpt

Immune-related toxicities, otherwise known as immune-related adverse events (irAEs), occur in a substantial fraction of cancer patients treated with immune checkpoint inhibitors (ICIs). Ranging from asymptomatic to life-threatening, ICI-induced irAEs can result in hospital admission, high-dose corticosteroid treatment, ICI discontinuation, and in some cases, death. A deeper understanding of the factors...

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PMID: 37491734
DOI: 10.1111/imr.13248

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