Article

Culture of Saos-2 cells under hypoxic conditions stimulates rapid differentiation to an osteocyte-like stage

2023-04-25

Abstract excerpt

1. Few human osteocyte in vitro models exist and the differentiation of immature osteoblasts to an osteocyte stage typically takes at least 4-weeks of culture, making the study of this process challenging and time consuming. The osteosarcoma cell line Saos-2 has proved to be a useful model of human osteoblast differentiation through to a mature osteocyte-like stage. Culture under osteogenic conditions in a standa...

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Literature Corpus work: 4f35c43c-3f38-5743-966c-b83f626305eb
DOI: 10.1101/2023.04.23.537998

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