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Article

Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs

5 Dec 2005

Abstract excerpt

Low oxygen tension is thought to be an integral component of the human mesenchymal stem cell (hMSC) native bone marrow microenvironment. HMSC were cultured under physiologically relevant oxygen environments (2% O2) in three-dimensional (3D) constructs for up to 1 month in order to investigate the combined effects of chronic hypoxia and 3D architecture on hMSC tissue-development patterns. Hypoxic hMSC exhibited an...

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PMID: 16331674
DOI: 10.1002/jcp.20571

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Source receipt: pubmed, retrieved 7 Sept 2026.

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