Article
Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells.
American journal of physiology. Cell physiology - 1 Feb 2010
Merceron Christophe, Vinatier Claire, Portron Sophie, Masson Martial, Amiaud Jérôme, Guigand Lydie, Chérel Yan, Weiss Pierre, Guicheux Jérôme
Abstract excerpt
Human adipose tissue-derived stem cells (hATSC) have been contemplated as reparative cells for cartilage engineering. Chondrogenic differentiation of hATSC can be induced by an enriched culture medium and a three-dimensional environment. Given that bone is vascularized and cartilage is not, oxygen tension has been suggested as a regulatory factor for osteochondrogenic differentiation. Our work aimed at...
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