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Article

Phenotypic instability of Saos-2 cells in long-term culture.

Biochemical and biophysical research communications - 22 Jul 2005

Hausser Heinz-Juergen, Brenner Rolf E

Abstract excerpt

The human osteosarcoma cell line Saos-2 is widely used as a model system for human osteoblastic cells, though its phenotypic stability has not been ascertained. We therefore propagated these cells over 100 passages and compared relevant phenotypic properties. In general, higher passage cells exhibited higher proliferation rates and lower specific alkaline phosphatase activities, though mineralization was...

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Identifiers

PMID: 15939397
DOI: 10.1016/j.bbrc.2005.05.097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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