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Article

Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2003

Shui Chaoxiang, Spelsberg Thomas C, Riggs B Lawrence, Khosla Sundeep

Abstract excerpt

Runx2/Cbfa1 has been identified as a "master gene" controlling osteoblast differentiation. However, its role in inducing the osteoblast phenotype has been characterized primarily in rodent systems. Thus, we examined Runx2/Cbfa1 messenger RNA, protein, and activity levels during osteoblastic differentiation of human bone marrow stromal (BMSC) cells. Semiquantitative reverse transcription-polymerase chain reaction...

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PMID: 12568398
DOI: 10.1359/jbmr.2003.18.2.213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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