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Article

Ex vivo expansion of human mesenchymal stem cells: a more effective cell proliferation kinetics and metabolism under hypoxia.

Journal of cellular physiology - 1 Apr 2010

Dos Santos Francisco, Andrade Pedro Z, Boura Joana S, Abecasis Manuel M, da Silva Cláudia Lobato, Cabral Joaquim M S

Abstract excerpt

The low bone marrow (BM) MSC titers demand a fast ex vivo expansion process to meet the clinically relevant cell dosage. Attending to the low oxygen tension of BM in vivo, we studied the influence of hypoxia on human BM MSC proliferation kinetics and metabolism. Human BM MSC cultured under 2% (hypoxia) and 20% O(2) (normoxia) were characterized in terms of proliferation, cell division kinetics and metabolic...

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Identifiers

PMID: 20020504
DOI: 10.1002/jcp.21987

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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