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Article

Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells.

Tissue engineering. Part C, Methods - 1 Jan 2013

Pattappa Girish, Thorpe Stephen D, Jegard Nick C, Heywood Hannah K, de Bruijn Joost D, Lee David A

Abstract excerpt

Mesenchymal stem cells (MSCs) are an attractive cell source for tissue engineering applications due to their multipotentiality and increased expansion potential compared to mature cells. However, the full potential of MSCs for cellular therapies is not realised, due, in part, to premature proliferative senescence and impaired differentiation capacity following expansion under 20% oxygen. Bone marrow MSCs reside...

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Identifiers

PMID: 22731854
DOI: 10.1089/ten.TEC.2011.0734

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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