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Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice

19 Mar 2025

Abstract excerpt

ABSTRACT The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying mechanisms remain elusive. This study delves into the previously unexplored role of autophagy in maintaining CNS myelin during aging. We generated the transgenic mouse line plpCre ERT2 ; atg5 f/f , enabling selective deletion of the core autophagic component Atg5 in oligodendrocytes (OLs) following tamoxifen...

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PMID: 40105013
DOI: 10.1002/glia.70012

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