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Cross-Tissue WGCNA Reveals Conserved Brain-Blood Transcriptomic Signatures and Potential Biomarkers for Asymptomatic Alzheimer's Disease Diagnosis

2026-07-12

Abstract excerpt

<title>Abstract</title> <p> Background Alzheimer’s disease (AD) is a neurodegenerative disorder characterised by a prolonged prodromal stage, often resulting in late diagnosis and limited therapeutic efficacy. Early diagnosis at the asymptomatic stage (AsymAD), before irreversible synaptic loss, is therefore critical. Although peripheral blood offers potential for early AD detection, biomarker discovery is limi...

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Literature Corpus work: 3c61928c-5328-5798-8b12-ac42016426c8
DOI: 10.21203/rs.3.rs-10229452/v1

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Cross-Tissue WGCNA Reveals Conserved Brain-Blood Transcriptomic Signatures and Potential Biomarkers for Asymptomatic Alzheimer's Disease DiagnosisDOI 10.21203/rs.3.rs-10229452/v1Read

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