Article

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

2020-08-11

Abstract excerpt

<h4>ABSTRACT</h4> Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The vast majority of these mutations are located in the inherently unstable DNA-binding domain (DBD), many of which destabilize the domain further and expose its aggregation-prone hydrophobic core, prompting self-assembly of mutant p53 into inactive cytosolic amyloid-like aggregates. Screening an oligo...

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Literature Corpus work: 7c8dd369-c927-56d3-9b84-6c1e64c42f73
DOI: 10.1101/2020.08.10.243154

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