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Genome-Wide CRISPR Screen Identifies Host Factors Required by Toxoplasma gondii Infection

21 Jan 2020

Abstract excerpt

Toxoplasma gondii are obligate intracellular protoza, and due to their small genome and limited encoded proteins, they have to exploit host factors for entry, replication, and dissemination. Such host factors can be defined as host dependency factors (HDFs). Though HDFs are inessential for cell viability, they are critical for pathogen infection and potential ideal targets for therapeutic intervention. However,...

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PMID: 32039045
DOI: 10.3389/fcimb.2019.00460

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