Article

Novel Role of Endothelial CD45 in Regulating Endothelial-to-Mesenchymal Transition in Atherosclerosis

2024-09-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The protein tyrosine phosphatase CD45 is expressed in all nucleated cells of the hematopoietic system and in mitral valve endothelial cells (ECs) undergoing endothelial-to-mesenchymal transition (EndoMT). Our recent work indicated that activation of endogenous CD45 in human endothelial colony-forming cells (ECFCs) induced expression of multiple EndoMT marker genes. We hypoth...

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Literature Corpus work: 4ebe4502-af1e-56cf-9414-647982590d6d
DOI: 10.1101/2024.09.03.610974

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