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Article

Endothelial-to-mesenchymal transition primes vascular endothelial cells toward an osteochondrogenic fate.

Vascular pharmacology - 1 Mar 2026

Kishta Franceska, Hall Ignacio Fernando, Li Guanliang, Tripathi Tanushree, Vermeren Matthieu, Cholewa-Waclaw Justyna, Rossi Fiona, Péault Bruno M, Rodor Julie, Beqqali Abdelaziz, Sluimer Judith C, Crisan Mihaela, Baker Andrew H

Abstract excerpt

Endothelial-to-mesenchymal transition (EndMT), in which endothelial cells (ECs) lose their endothelial identity and acquire mesenchymal-like features, contributes to vascular dysfunction and remodeling in atherosclerosis. However, the fate and function of these cells remain unclear. Here, we investigated their differentiation potential and functional properties to define how EndMT contributes to vascular...

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Identifiers

PMID: 41475635
DOI: 10.1016/j.vph.2025.107579

Genes

CD44
MSC
ANXA6
BMPR1A
CD151
DCN
NOTCH2
RUNX2
WNT5A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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