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Article

The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease

10 Jan 2023

Abstract excerpt

Parkinson's disease (PD) is a chronic neurodegenerative disease that is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain (SNpc). Extensive studies into genetic and cellular models of PD implicate protein trafficking as a prominent contributor to the death of these dopaminergic neurons. Considerable evidence also suggests the involvement of α-synuclein as a...

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PMID: 36704248
DOI: 10.3389/fncel.2022.1081426

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