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Investigating the role of opiorphin genes in prostate cancer and the possible genetic mechanisms by which they modulate tumor growth and androgen-sensitivity

2019-10-09

Abstract excerpt

<title>Abstract</title> <p>Background The opiorphin family of genes (represented in humans by ProL1, hSMR3A and hSMR3B) encode peptides which act as potent neutral endopeptidase (NEP) inhibitors. Because modulated NEP activity is associated with cancer development, several years ago a review postulated that dysregulated opiorphin expression may be involved in oncogenesis. This has recently been supported by repor...

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Literature Corpus work
4e9c3365-f5ff-5828-b1d8-1836d4bcd3fe
DOI
10.21203/rs.2.15829/v1
Open publication

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