Article

Iroquois homeobox 4 (IRX4) Derived Micropeptide Promotes Prostate Cancer Progression and Chemoresistance Through Wnt Signaling Dysregulation

2023-10-28

Abstract excerpt

<title>Abstract</title> Background Genome-wide association studies have implicated Iroquois (IRX) gene clusters in cancer susceptibility, yet their functional roles remain unclear. Micropeptides (miPEPs), short open reading frames (sORFs) encoding small peptides, have emerged as regulators of diverse biological processes. However, the significance of cancer-related miPEPs in tumorigenesis and therapy response...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1787fc09-d4db-5a1f-9f4f-c1f106bff684
DOI: 10.21203/rs.3.rs-3154829/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Iroquois homeobox 4 (IRX4) Derived Micropeptide Promotes Prostate Cancer Progression and Chemoresistance Through Wnt Signaling DysregulationDOI 10.21203/rs.3.rs-3154829/v1Read

Identification of a Micropeptide Linked to Cancer Stem Cell Regulation and ChemoresistanceSemantic proximity Read

Iroquois homeobox 4 (IRX4) derived micropeptide promotes prostate cancer progression and chemoresistance through Wnt signalling dysregulationSemantic proximity Read

Signatures of Micropeptides Encoded by lncRNAs in Cancer Progression and MetastasisSemantic proximity Read

Unveiling prognostic genes and regulatory mechanisms of exosome in prostate cancer: an integrated analysis of bulk transcriptomics and single-cell RNA sequencing dataSemantic proximity Read

Unravelling the Role of Iroquois Homeobox 4 and its Interplay with Androgen Receptor in Prostate CancerSemantic proximity Read

Exploring the Dark Matter of Human Proteome: The Emerging Role of Non-Canonical Open Reading Frame (ncORF) in Cancer Diagnosis, Biology, and TherapySemantic proximity Read

ENOX1, CCDC122ANDLACC1ROLE IN PROGRESSION OF PROSTATE CANCERSemantic proximity Read

X-Linked Cancer-Associated Polypeptide (XCP) from lncRNA1456 Cooperates with PHF8 to Regulate Gene Expression and Cellular Pathways in Breast CancerSemantic proximity Read

Oncopeptide MBOP Encoded by LINC01234 Promotes Colorectal Cancer through MAPK Signaling PathwaySemantic proximity Read

The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition.Semantic proximity Read

The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read

The long transcript of lncRNA TMPO-AS1 promotes bone metastases of prostate cancer by regulating the CSNK2A1/DDX3X complex in Wnt/β-catenin signalingSemantic proximity Read