Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

1 Jan 2021

Abstract excerpt

Potent therapeutic inhibition of the androgen receptor (AR) in prostate adenocarcinoma can lead to the emergence of neuroendocrine prostate cancer (NEPC), a phenomenon associated with enhanced cell plasticity. Here, we show that microRNA-194 (miR-194) is a regulator of epithelial-neuroendocrine transdifferentiation. In clinical prostate cancer samples, miR-194 expression and activity were elevated in NEPC and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to FOXO transcription factor regulation
Share to MicroRNA in disease regulation
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33406413
DOI: 10.1016/j.celrep.2020.108585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate CancerPMID 33406413Read ↗

MicroRNA-194 promotes lineage plasticity in advanced prostate cancerSemantic proximity Read ↗

Gene Expression Signature Predictive of Neuroendocrine Transformation in Prostate AdenocarcinomaSemantic proximity Read ↗

Cellular plasticity and the neuroendocrine phenotype in prostate cancer.Semantic proximity Read ↗

Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancerSemantic proximity Read ↗

Neuroendocrine transdifferentiation in human cancer: molecular mechanisms and therapeutic targetsSemantic proximity Read ↗

The Many Faces of Neuroendocrine Differentiation in Prostate Cancer ProgressionSemantic proximity Read ↗

Role of MicroRNAs in Neuroendocrine Prostate CancerSemantic proximity Read ↗

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancerSemantic proximity Read ↗

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer.Semantic proximity Read ↗

Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancerSemantic proximity Read ↗

Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiationSemantic proximity Read ↗

Therapeutic Exploitation of Neuroendocrine Transdifferentiation Drivers in Prostate CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.