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Article

Prep1 (pKnox1)‐deficiency leads to spontaneous tumor development in mice and accelerates EμMyc lymphomagenesis: A tumor suppressor role for Prep1

7 Jan 2010

Abstract excerpt

The Prep1 homeodomain transcription factor is essential for embryonic development. 25% of hypomorphic Prep1(i/i) embryos, expressing the gene at 2% of the normal levels, survive pregnancy and live a normal-length life. Later in life, however, these mice develop spontaneous pre-tumoral lesions or solid tumors (lymphomas and carcinomas). In addition, transplantation of E14.5 fetal liver (FL) Prep1(i/i) cells into...

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Identifiers

PMID: 20106730
DOI: 10.1016/j.molonc.2010.01.001

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Prep1 (pKnox1)‐deficiency leads to spontaneous tumor development in mice and accelerates EμMyc lymphomagenesis: A tumor suppressor role for Prep1PMID 20106730Read ↗

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