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Article

A novel role for Neurog2 in MYCN driven neuroendocrine plasticity of prostate cancer

2024-11-08

Abstract excerpt

<title>Abstract</title> <p>Neuroendocrine prostate cancer (NEPC) presents a formidable clinical challenge owing to its aggressive progression and resistance to conventional therapies. A key driver of NEPC is the overexpression of <italic>MYCN</italic>, a well-established oncogene associated with neuroendocrine tumors. However, efforts to directly inhibit the N-Myc protein encoded by this gene have resulted in lim...

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Literature Corpus work
a0ec4265-6ca3-544e-8461-1cff4ed862d3
DOI
10.21203/rs.3.rs-5313977/v1
Open publication

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