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Article

Modulation of toxin production by the flagellar regulon in Clostridium difficile.

Infection and immunity - 1 Oct 2012

Aubry Annie, Hussack Greg, Chen Wangxue, KuoLee Rhonda, Twine Susan M, Fulton Kelly M, Foote Simon, Carrillo Catherine D, Tanha Jamshid, Logan Susan M

Abstract excerpt

We show in this study that toxin production in Clostridium difficile is altered in cells which can no longer form flagellar filaments. The impact of inactivation of fliC, CD0240, fliF, fliG, fliM, and flhB-fliR flagellar genes upon toxin levels in culture supernatants was assessed using cell-based cytotoxicity assay, proteomics, immunoassay, and immunoblotting approaches. Each of these showed that toxin levels in...

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Identifiers

PMID: 22851750
DOI: 10.1128/IAI.00224-12
PMCID: PMC3457548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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