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Article

TCF-1 negatively regulates the suppressive ability of canonical and noncanonical Tregs.

Journal of leukocyte biology - 2 May 2023

Mammadli Mahinbanu, Suo Liye, Sen Jyoti Misra, Karimi Mobin

Abstract excerpt

Regulatory T cells are suppressive immune cells used in various clinical and therapeutic applications. Canonical regulatory T cells express CD4, FOXP3, and CD25, which are considered definitive markers of their regulatory T-cell status when expressed together. However, a subset of noncanonical regulatory T cells expressing only CD4 and FOXP3 have recently been described in some infection contexts. Using a unique...

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Identifiers

PMID: 36806938
DOI: 10.1093/jleuko/qiad019
PMCID: PMC11651127

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