Article

TOX enforces the immunosuppressive program of tumor-infiltrating regulatory T cells

2026-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Regulatory T (Treg) cells accumulate in the tumor microenvironment (TME) to suppress anti-tumor immunity, but the transcriptional regulators stabilizing their immunosuppressive state remain poorly defined. Here we show that transcriptional factor TOX is selectively upregulated in tumor-infiltrating (TI) Treg cells across human cancers and mouse tumor models, while remaining low in peripheral and...

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Literature Corpus work: e66ae436-ced4-5965-91e8-cbd95d241a7d
DOI: 10.64898/2026.06.19.732838

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