Article
Effector memory-type regulatory T cells display phenotypic and functional instability.
Science advances - 6 Sept 2024
Wendering Désirée Jacqueline, Amini Leila, Schlickeiser Stephan, Farrera-Sal Martí, Schulenberg Sarah, Peter Lena, Mai Marco, Vollmer Tino, Du Weijie, Stein Maik, Hamm Frederik, Malard Alisier, Castro Carla, Yang Mingxing, Ranka Ramon, Rückert Timo, Durek Pawel, Heinrich Frederik, Gasparoni Gilles, Salhab Abdulrahman, Walter Jörn, Wagner Dimitrios Laurin, Mashreghi Mir-Farzin, Landwehr-Kenzel Sybille, Polansky Julia K, Reinke Petra, Volk Hans-Dieter, Schmueck-Henneresse Michael
Abstract excerpt
Regulatory T cells (Treg cells) hold promise for sustainable therapy of immune disorders. Recent advancements in chimeric antigen receptor development and genome editing aim to enhance the specificity and function of Treg cells. However, impurities and functional instability pose challenges for the development of safe gene-edited Treg cell products. Here, we examined different Treg cell subsets regarding their...
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