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Article

Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR-T-cell responses against ALL.

Blood - 15 Jul 2021

Zheng Wenting, Wei Jun, Zebley Caitlin C, Jones Lindsay L, Dhungana Yogesh, Wang Yong-Dong, Mavuluri Jayadev, Long Lingyun, Fan Yiping, Youngblood Ben, Chi Hongbo, Geiger Terrence L

Abstract excerpt

Chimeric antigen receptor (CAR)-T-cell therapeutic efficacy is associated with long-term T-cell persistence and acquisition of memory. Memory-subset formation requires T-cell factor 1 (TCF-1), a master transcription factor for which few regulators have been identified. Here, we demonstrate using an immune-competent mouse model of B-cell acute lymphoblastic leukemia (ALL; B-ALL) that Regnase-1 deficiency promotes...

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Identifiers

PMID: 33690816
DOI: 10.1182/blood.2020009309
PMCID: PMC8288655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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