NiCo Identifies Extrinsic Drivers of Cell State Modulation by Niche Covariation Analysis

Abstract excerpt

Cell states are modulated by intrinsic driving forces such as gene expression noise and extrinsic signals from the tissue microenvironment. The distinction between intrinsic and extrinsic cell state determinants is essential for understanding the regulation of cell fate in tissues during development, homeostasis and disease. The rapidly growing availability of single-cell resolution spatial transcriptomics makes i...

Topics

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• AI in cancer detection
• Colorectal Cancer Screening and Detection
• Gene Expression Profiling
• Phenotype
• Radiomics and Machine Learning in Medical Imaging
• Single-cell and spatial transcriptomics
• Technology
• Transcriptome

Identifiers and source

Literature Corpus work

1ca0de11-a74a-5e54-80d3-bcb8c59b2ac4

DOI

10.1101/2024.09.08.611848