Article

The gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood

2025-04-23

Abstract excerpt

The polygenic risk score genetic quantitative ultrasound speed of sound (gSOS) was developed using machine learning algorithms in adults of European ancestry and associates with reduced odds of fracture in adults. We aimed to determine if gSOS was associated with bone health in children. Two observational studies of children were evaluated: (1) children enrolled in the Bone Mineral Density in Childhood Study (BMDC...

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Literature Corpus work: 4e587f14-63dc-5849-9159-60086b2148af
DOI: 10.1101/2025.04.22.25325387

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