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Article

Increased Burden of Common Risk Alleles in Children With a Significant Fracture History.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2020

Manousaki Despoina, Kämpe Anders, Forgetta Vincenzo, Makitie Riikka E, Bardai Ghalib, Belisle Alexandre, Li Rui, Andersson Sture, Makitie Outi, Rauch Frank, Richards J Brent

Abstract excerpt

Extreme presentations of common disease in children are often presumed to be of Mendelian etiology, but their polygenic basis has not been fully explored. We tested whether children with significant fracture history and no osteogenesis imperfecta (OI) are at increased polygenic risk for fracture. A childhood significant fracture history was defined as the presence of low-trauma vertebral fractures or multiple...

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PMID: 31914204
DOI: 10.1002/jbmr.3956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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