Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study.

doi:10.1371/journal.pmed.1003152

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Article

Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study.

PLoS medicine - 1 Jul 2020

Forgetta Vincenzo, Keller-Baruch Julyan, Forest Marie, Durand Audrey, Bhatnagar Sahir, Kemp John P, Nethander Maria, Evans Daniel, Morris John A, Kiel Douglas P, Rivadeneira Fernando, Johansson Helena, Harvey Nicholas C, Mellström Dan, Karlsson Magnus, Cooper Cyrus, Evans David M, Clarke Robert, Kanis John A, Orwoll Eric, McCloskey Eugene V, Ohlsson Claes, Pineau Joelle, Leslie William D, Greenwood Celia M T, Richards J Brent

Abstract excerpt

BACKGROUND: Since screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could decrease the number needing to be screened by removing individuals at low genetic risk. We therefore tested whether a polygenic risk score for heel quantitative ultrasound speed of sound (SOS)-a heritable risk factor for osteoporotic...

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PMID: 32614825
DOI: 10.1371/journal.pmed.1003152
PMCID: PMC7331983

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