Article

ABCA1 deficiency causes tissue-specific dysregulation of the SREBP2 pathway in mice

2024-02-22

Abstract excerpt

The ATP-binding cassette transporter ABCA1 plays an essential role in the formation of high-density lipoprotein (HDL) by mediating phospholipid and cholesterol efflux to apolipoprotein A-I. In humans, loss-of-function mutations in the ABCA1 gene cause Tangier disease (TD), a familial HDL deficiency. In addition to the disappearance of HDL, TD patients and Abca1 -/- mice exhibit the cholesterol deposition in peri...

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Literature Corpus work: c015fdbd-fd07-5bcc-9c35-cfa43105d62b
DOI: 10.1101/2024.02.20.580966

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