Article
Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2010
Tarling Elizabeth J, Bojanic Dragana D, Tangirala Rajendra K, Wang Xuping, Lovgren-Sandblom Anita, Lusis Aldons J, Bjorkhem Ingemar, Edwards Peter A
Abstract excerpt
OBJECTIVE: To generate Abcg1(-/-) Apoe(-/-) mice to understand the mechanism and cell types involved in changes in atherosclerosis after loss of ABCG1. METHODS AND RESULTS: ABCG1 is highly expressed in macrophages and endothelial cells, 2 cell types that play important roles in the development of...
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