Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathophysiologic abnormalities in transgenic mice carrying the Alzheimer disease PSEN1 Δ440 mutation.

Human molecular genetics - 20 Nov 2024

Fuller Peyton E, Collis Victoria L, Sharma Pallavi, Burkett Angelina M, Wang Shaoteng, Brown Kyle A, Weir Nick, Goulbourne Chris N, Nixon Ralph A, Longden Thomas A, Gould Todd D, Monteiro Mervyn J

Abstract excerpt

Mutations in PSEN1 were first discovered as a cause of Alzheimer's disease (AD) in 1995, yet the mechanism(s) by which the mutations cause disease still remains unknown. The generation of novel mouse models assessing the effects of different mutations could aid in this endeavor. Here we report on transgenic mouse lines made with the Δ440 PSEN1 mutation that causes AD with parkinsonism:- two expressing the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippocampus

Share to Mice, Transgenic

Share to Mutation

Share to Neurons

Share to Presenilin-1

Source

Open in PubMed Open full text

Identifiers

PMID: 39323410
DOI: 10.1093/hmg/ddae139
PMCID: PMC11578115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathophysiologic abnormalities in transgenic mice carrying the Alzheimer disease PSEN1 Δ440 mutation.PMID 39323410Read ↗

Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease ResearchSemantic proximity Read ↗

Mammalian Models in Alzheimer's Research: An updateSemantic proximity Read ↗

Comparison of memory, affective behavior, and neuropathology in APPNLGF knock-in mice to 5xFAD and APP/PS1 miceSemantic proximity Read ↗

Mutant genes in familial Alzheimer's disease and transgenic models.Semantic proximity Read ↗

The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model.Semantic proximity Read ↗

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?Semantic proximity Read ↗

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes.Semantic proximity Read ↗

Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's diseaseSemantic proximity Read ↗

Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.Semantic proximity Read ↗

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic miceSemantic proximity Read ↗

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.Semantic proximity Read ↗

Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.